What are the indications and contraindications to MTX?
When should they follow up with their obstetrician?
Answer: In 4 days for a repeat b-HCG and possible second dose of MTX
Note that one of the eligibility criteria is that the patient must have an "unruptured ectopic pregnancy". Many would consider that any ultrasonographic evidence of free fluid may be a sign of an early rupture. It is left up to clinician judgment in how "unruptured" is interpreted.
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 94: Medical management of ectopic pregnancy. Obstet Gynecol. 2008 Jun;111(6):1479-85.